The MDM4 POLYCLONAL ANTIBODY from Bioss Inc. is a Rabbit Polyclonal antibody to MDM4, and MDM4 regulator of p53. This antibody recognizes Mouse antigen. The MDM4 POLYCLONAL ANTIBODY has been validated for the following applications: EIA, Immunoassay, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, Immunohistochemistry - frozen, and Western Blot.
Description
Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions